Just when you thought it was safe to put away your fiber wire, IO Interactive pulls you back in. At The Game Awards 2025, the studio unveiled the next major chapter for Hitman: World of Assassination, and it is a star-studded affair. Titled Patient Zero Requiem, this new content update features none other than action icon Milla Jovovich as a brand-new Elusive Target.
Following the bizarrely entertaining “Slim Shady” mission where Agent 47 had to take out Eminem’s alter ego, IOI is pivoting back to something a bit more serious—and deadly. The trailer teased a high-stakes scenario involving a viral outbreak, aiming to raise the tension back to the levels of the original Patient Zero campaign. Here is everything we know about Agent 47’s next contract.
Milla Jovovich Enters the World of Assassination
The trailer was brief but effective. We see Milla Jovovich—famous for her roles in Resident Evil and The Fifth Element—stepping into the shoes of a character that seems fully aware of the danger she poses. The voiceover warns, “One touch can be deadly,” hinting that the viral mechanics from the 2017 Patient Zero campaign are making a comeback. Jovovich appears to be playing a key figure in this new outbreak, possibly a scientist or a carrier who needs to be “contained” permanently.
This continues IOI’s recent trend of integrating real-world celebrities into the game’s lore, transforming them into high-value targets. Unlike the Sean Bean “Undying” character who kept coming back, this mission is framed as a “Requiem,” suggesting a finality to the Patient Zero storyline.
Return to the Virus Mechanics?
Veterans of the series remember the “Hokkaido” mission from the original Patient Zero campaign with a mix of fondness and dread. The mechanic where the virus could spread from NPC to NPC, potentially infecting the entire map (and the player), created one of the most chaotic and challenging experiences in Hitman history.
The title Patient Zero Requiem strongly implies we will be revisiting this intense gameplay loop. The challenge won’t just be assassinating Jovovich’s character; it will be doing so without letting a pandemic start in the middle of the level. It adds a layer of urgency that standard contracts just don’t have.
Release Date
You won’t have to wait long to plan your approach. Patient Zero Requiem is scheduled to launch in February 2026. It will be available as a free update for owners of Hitman: World of Assassination on all major platforms, including PS5, Xbox Series X|S, and PC. This gives you just enough time to practice your suit-only runs and remember where the hazmat suits are hidden.
Conclusion
IO Interactive continues to prove that Hitman: World of Assassination is the gift that keeps on giving. By bringing in a star like Milla Jovovich and revisiting one of their most unique gameplay mechanics, they are keeping the game fresh years after release. Whether you are a stealth purist or just want to see Milla in digital form, February 2026 is going to be a busy month for assassins.
FAQs
When is the Milla Jovovich mission releasing?
The content is set to release in February 2026.
Is this a paid DLC?
It is announced as part of the World of Assassination live service updates, which are typically free for existing owners, though specific access details may vary.
What is Patient Zero?
Patient Zero was a DLC campaign for the 2016 Hitman game that introduced a viral infection mechanic, where the virus could spread between characters in real-time.
Will there be new maps?
Likely not. Previous celebrity Elusive Targets have reused existing maps (like Miami or Paris) with significant visual and layout changes to fit the new mission.
Is Hitman 4 coming out soon?
IO Interactive has confirmed that a new Hitman game is planned, but their current focus is on the 007 Project and supporting World of Assassination.